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| ZESTRIL
IS INDICATED AS ADJUNCTIVE THERAPY FOR HEART FAILURE PATIENTS NOT
RESPONDING ADEQUATELY TO DIURETICS AND DIGITALIS |
- Significantly improved ejection fraction7,8
- Improved exercise tolerance7,9
- Adverse events occurring in greater than 2.5% of patients with heart failure treated with ZESTRIL and at a greater incidence than with placebo were dizziness (11.8% vs 4.5%), hypotension (4.4% vs 0.6%), headache (4.4% vs 3.9%), diarrhea (3.7% vs 1.9%), and chest pain (3.4% vs 1.3%)
- Pharmacokinetic studies indicate that maximum blood levels and area under the
plasma concentration time curve are doubled in older patients,
so that dosage adjustments should be made with particular caution
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Patient Profile
Treatment of Heart Failure Symptoms
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Evaluation of patients with hypertension, heart failure, or MI should always include assessment of renal function (see DOSAGE AND ADMINISTRATION).
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